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                                                                                                                                                                                Pseudomyxoma Peritonei Surgery and Treatment

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                                                                                                                                                                                We're "veterans" of pseudomyxoma peritonei surgery and we'll support you!






                                                                                                                                                                                How is PMP treated?

                                                                                                                                                                                What are the treatment options for Pseudomyxoma Peritonei?

                                                                                                                                                                                Is surgery required for Pseudomyxoma Peritonei treatment?

                                                                                                                                                                                What treatment therapy is standard care for Pseudomyxoma Peritonei syndrome treatment?

                                                                                                                                                                                What are CRS surgery and HIPEC therapy?

                                                                                                                                                                                Are you or a loved one preparing for surgery for the treatment of Pseudomyxoma Peritonei syndrome?

                                                                                                                                                                                The PMP Pals' Network provides a wide variety of services to assist you in preparing for, and recuperating from, surgery as quickly as possible!

                                                                                                                                                                                Our 2012  Preparing for Surgery Handbook and Newsletters provide step by step instructions to assist you with preparing for and recuperating from treatment.


                                                                                                                                                                                Our Pal Mentors will personally communicate with you via telephone, email, personal visits, SKYPE or web cam to help you, or your loved one prepare for surgery and/or HIPEC. We will share helpful resources and positive information to guide you through your recuperation!

                                                                                                                                                                                We are here to assist you in returning to your full and active life, as soon as possible!

                                                                                                                                                                                View photos and profiles of successful surgery survivors!

                                                                                                                                                                                Pseudomyxoma Peritonei Surgery, HIPEC and Chemotherapy overview


                                                                                                                                                                                Your surgical oncologist will explain and review all treatment options for Pseudomyxoma Peritonei. Your treatment plan will depend on your overall health, the type of tumor (pathology), the quantity (mass) size and location of the tumor, and whether the cancer has metastasized.

                                                                                                                                                                                Treatment for the Pseudomyxoma Peritonei syndrome generally includes CRS or cytoreductive surgery with or without systemic chemotherapy and HIPEC.

                                                                                                                                                                                The purpose of  debulking surgery is to remove as much tumor as possible. Debulking surgery often includes the removal of the omentum and the right colon. Additionally, for women, debulking will likely include a hysterectomy, if this was not perfomed previously. Adhesions become more troublesome with any additional debulking surgeries.

                                                                                                                                                                                Cytoreductive surgery is a detailed, lengthy procedure often requiring ten or more hours.
                                                                                                                                                                                Tumors are removed and destroyed using a variety of surgical techniques including argon beam coagulator, electro-evaporation, laser, and ultrasonic dissection.

                                                                                                                                                                                CRS (cytoreductive surgery)
                                                                                                                                                                                consists of the removal of as much mucin and visible tumor as possible, from the abdominal cavity. CRS surgery, refers to the removal of all visible tumors present throughout the peritoneal cavity. Cytoreductive Surgery includes thorough removal or destruction of all visible tumors throughout the surfaces of the peritoneum. Surgery may include the removal or resection of segments of small and large bowel, gall bladder, liver, omentum, ovaries, pancreas, spleen, stomach and uterus, and
                                                                                                                                                                                may require removing the lining of the peritoneum.

                                                                                                                                                                                Hemicolectomy is a surgical procedure involving the removal of a portion of the colon next to the appendix. This procedure may also include the removal of nearby blood vessels and lymph nodes at the same time.

                                                                                                                                                                                Peritonectomy refers to stripping the parietal peritoneum and resecting structures at the sites that contain adenomucinosis. A combination of surgical techniques are utilized including organ resection, when necessary and tumor destruction via electro-evaporation and argon beam coagulation.

                                                                                                                                                                                CRS surgery for Appendix Cancer and Pseudomyxoma Peritonei may include the following:

                                                                                                                                                                                Removal of the omentum, spleen and gall bladder,
                                                                                                                                                                                Right hemicolectomy, colectomy, removal of the rectum and sigmoid,
                                                                                                                                                                                Stripping tumor from the surface of the liver,
                                                                                                                                                                                Resection of the pancreas,
                                                                                                                                                                                Gastrectomy (partial or total removal of the stomach)
                                                                                                                                                                                Stripping the peritoneum from left and right hemidiaphragm;
                                                                                                                                                                                Pelvic peritonectomy,
                                                                                                                                                                                Ileostomy,
                                                                                                                                                                                colostomy or urostomy

                                                                                                                                                                                HIPEC may be included at the conclusion of the cytoreductive surgery for the treatment of pseudomyxoma peritonei and appendix cancer if substantial tumor debulking is accomplished through CRS. HIPEC may be administered when complete removal of visible tumor (or debulking) is achieved through cytoreductive surgery; it involves perfusion of the peritoneal cavity with chemotherapy heated to approximately 40 degrees Celsius.

                                                                                                                                                                                HIPEC is administered with the infusion of heated chemotherapy during the last 90 minutes of the CRS procedure. Through HIPEC the surgeon(s) intend to destroy any residual tumor cells that may not have been surgically removed during the actual CRS surgery process.

                                                                                                                                                                                Although this procedure may initially sound drastic to the newly diagnosed patient, rarely is resection and/or removal of all of these organs is required.
                                                                                                                                                                                Each patient's case is unique and most patients live productive and healthy lives following surgery!

                                                                                                                                                                                Learn about HIPEC

                                                                                                                                                                                Learn how to prepare for surgery
                                                                                                                                                                                Order the PMP Pals' Network Handbook: Preparing for Surgery.*

                                                                                                                                                                                Slideshow "Getting Ready for Surgery" provides generic surgery information
                                                                                                                                                                                Presented by WB MD, August 2010


                                                                                                                                                                                Ostomies

                                                                                                                                                                                Request a Pal Mentor to help you prepare for and recuperate from surgery!


                                                                                                                                                                                Our Pal Mentors are "veterans" of surgery with Drs. Ahrendt, Bartlett, Esquivel, Goodman, Holtzman,Levine, Loggie, Lowy, Mansfield, Moran, Morris, Pingpank, Temple, Sardi, Shen, Stewart, Sugarbaker, Selby and Zeh!


                                                                                                                                                                                Learn more about systemic Chemotherapy

                                                                                                                                                                                CRS (Cytoreductive Surgery) in conjunction with HIPEC: Articles and Abstracts

                                                                                                                                                                                This week's featured articles:


                                                                                                                                                                                Upfront Compared to Delayed Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei Is Associated With Considerably Lower Perioperative Morbidity and Recurrence Rate.
                                                                                                                                                                                Chua TC, Liauw W, Zhao J, Morris DL.

                                                                                                                                                                                *UNSW Department of Surgery, St George Hospital, Kogarah, Sydney, Australia. †Department of Medical Oncology, Cancer Care Centre, St George Hospital, Kogarah, Sydney, Australia.

                                                                                                                                                                                Abstract

                                                                                                                                                                                BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a recognized management strategy for pseudomyxoma peritonei. We seek to evaluate the outcomes of patients treated upfront with CRS PIC compared to patients undergoing delayed CRS PIC as salvage or treatment for recurrences after initial debulking surgery.

                                                                                                                                                                                METHODS: Retrospective analysis of patients with low-grade pseudomyxoma peritonei treated within our institution were stratified according to upfront versus delayed CRS PIC after intial debulking surgery. Survival was analyzed using the Kaplan-Meier method and compared using the log-rank test.

                                                                                                                                                                                RESULTS: Of 83 patients treated, 35 patients (42%) underwent upfront and 48 patients (58%) underwent delayed CRS PIC. The peritoneal cancer index (P = 0.048), amount of blood transfusion intraoperatively (P = 0.003) and duration of operation (P = 0.007) was lesser in the upfront compared to delayed group. Upfront treatment confers 5-year recurrence-free survival benefit (77% vs 37%; P = 0.011) and 10-year overall survival benefit (67% vs 35%; P = 0.054) over delayed treatment.

                                                                                                                                                                                CONCLUSION: Upfront CRS PIC seems to confer beneficial perioperative outcomes and lower recurrence rates over delayed CRS PIC. Early referral to centralized treatment centers would seem to be a reasonable strategy to improve outcomes.

                                                                                                                                                                                Source: Annals of Surgical Oncology, Jan 13, 2011

                                                                                                                                                                                Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Limited Peritoneal Surface Malignancies: Feasibility, Morbidity and Outcome in an Early Experience.

                                                                                                                                                                                Laparoscopic CRS and HIPEC in Patients with Limited PSMs

                                                                                                                                                                                Source: Esquivel J, Averbach A, Chua TC  St. Agnes Hospital, Baltimore, Maryland.

                                                                                                                                                                                Ann Surg. 2011 Jan 6. [Epub ahead of print]

                                                                                                                                                                                Abstract

                                                                                                                                                                                INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being widely used in the treatment of patients with peritoneal surface malignancies. The open procedure has been associated with high grade III and IV morbidity and prolonged hospitalization.

                                                                                                                                                                                METHODS: Patients with peritoneal surface malignancies and no gross evidence of carcinomatosis on the computed tomographic scan were enrolled to undergo laparoscopic CRS and HIPEC. We aimed to assess the feasibility, safety, and outcome of this procedure. Postoperative complications were reported according to the National Cancer Institute Common Toxicity Criteria.

                                                                                                                                                                                RESULTS: From October 2008 to January 2010, 14 patients were enrolled into the protocol. Amongst these 14 patients, one patient was found with extensive carcinomatosis at the time of laparoscopy and had no surgical procedure. Thirteen patients had a complete cytoreduction and HIPEC, 10 (77%) laparoscopically and 3 (23%) were converted to an open procedure. There was one grade 3 morbidity (10%) and one patient (10%) in the laparoscopy group experienced a grade 4 complication, needing a reoperation for an internal hernia. Mean length of hospital stay was 6 days for those completed laparoscopically, 8 days for those converted to an open procedure and 8 days for a matched cohort of patients with an upfront open procedure.

                                                                                                                                                                                CONCLUSIONS: This initial investigative stage demonstrates the feasibility and safety of cytoreductive surgery and HIPEC via the laparoscopic route in selected patients with low-tumor volume and no small bowel involvement mainly from appendiceal malignancies. Longer follow-up and additional studies are required to evaluate its long-term efficacy.

                                                                                                                                                                                PMID: 21217512 [PubMed - as supplied by publisher] January 2011


                                                                                                                                                                                Study of 300+ Patients Treated with CRS and PIC


                                                                                                                                                                                Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                                Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                                Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                                Radiofrequency Ablation for Treatment of Unresectable Colorectal Pulmonary Metastes


                                                                                                                                                                                Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Radiofrequency ablation for colorectal pulmonary metastases represents a step forward towards a nonsurgical option of combining systemic and local treatment for metastatic disease and is a safe treatment with a low risk profile.

                                                                                                                                                                                Terence C. Chua, BScMed (Hons), MBBS 1, Kelly Thornbury, BMed 1, Akshat Saxena, BMedSc 1, Winston Liauw, MBBS, M Med Sci 2, Derek Glenn, MBBS 3, Jing Zhao, MD 1, David L. Morris, MD, PhD 1 *
                                                                                                                                                                                1Department of Surgery, University of New South Wales, St George Hospital, Sydney, Australia
                                                                                                                                                                                2Cancer Care Center, St George Hospital, Sydney, Australia
                                                                                                                                                                                3Department of Radiology, St George Hospital, Sydney, Australia
                                                                                                                                                                                Source: AMC Feb 2010 

                                                                                                                                                                                Treatment of Peritoneal Malignancies, including Pseudomyxoma Peritonei with CRS and HIPEC

                                                                                                                                                                                CONCLUSION: It is important to recognize the role of and indications for CRS and HIPEC. Biologic factors of the disease and completeness of resection are important prognostic factors. Cytoreductive surgery, combined with intraperitoneal chemotherapy, can improve survival in selected patients with peritoneal-based malignancies.

                                                                                                                                                                                Source:Department of Surgical Oncology, National Cancer Centre of Singapore, Singapore 2010

                                                                                                                                                                                Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                                Source: Journal of Clinical Oncology,2010

                                                                                                                                                                                12 Year Study of CRS and HIPEC for Pseudomyxoma Peritonei Treatment
                                                                                                                                                                                Source: In Vivo, 2009


                                                                                                                                                                                Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan



                                                                                                                                                                                CRS with HIPEC have improved quality and quantity of life for patients
                                                                                                                                                                                Source:Dr Brian Loggie, 2007

                                                                                                                                                                                HIPEC: Complexity
                                                                                                                                                                                Source: Dr David L Bartlett,Journal of Surgical Oncology

                                                                                                                                                                                Twelve year study of Pseudomyxoma Peritonei Treatment with CRS and HIPEC
                                                                                                                                                                                Source: San Giuseppe Hospital, June 2009

                                                                                                                                                                                Pleural Pseudomyxoma Peritonei Treatment with Thoracic CRS and HIPEC
                                                                                                                                                                                Source: University of New South Wales, Australia, 2009

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with CRS and HIPEC
                                                                                                                                                                                Source: Universite de Montreal, Canada, 2009

                                                                                                                                                                                HIPEC Treatment provided at St Agnes
                                                                                                                                                                                Source: Dr Jesus Esquivel

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with Cytoreductive Surgery and HIPEC
                                                                                                                                                                                Source: British Journal of Surgery, Aug 2008

                                                                                                                                                                                Tailgut Cyst: An Unusual Case of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Tumori, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with Chemo Hyperthermic Perfusion(CHPP)
                                                                                                                                                                                Source: Pub Med 2009

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annuals of Surgical Oncology, 2008
                                                                                                                                                                                International Consensus of PSMG for CRS and HIPEC
                                                                                                                                                                                Source: Springerlink, Oct 2006


                                                                                                                                                                                Recommended Reading:

                                                                                                                                                                                Questions Patients Need to Ask by Dr David Shulkin
                                                                                                                                                                                Source: Amazon.com, Barnes and Noble, Ebay


                                                                                                                                                                                Read ratings for physicians across the USA

                                                                                                                                                                                Alpha Index of  Surgery Articles by "PMP" Cancer Specialists

                                                                                                                                                                                International  listing of research articles and abstracts

                                                                                                                                                                                See our
                                                                                                                                                                                SURGEONS & SPECIALISTS link for additional information about these physicians.
                                                                                                                                                                                We provide the following abstracts and articles, published by, and/or written about the world's most experienced specialists in the treatment and research of Pseudomyxoma Peritonei, and Appendix Cancer. The full titles of some abstracts have been abbreviated due to space limitations.

                                                                                                                                                                                Articles by Dr SA Ahrendt, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                                Source: Journal of Clinical Oncology 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                                Articles by Dr Fernando Arias, Colombia

                                                                                                                                                                                Sleeve Gastrectomy
                                                                                                                                                                                Source: Fundacion Santa Fe de Bogota


                                                                                                                                                                                Abstracts by Dr Mario Baratti, Italy

                                                                                                                                                                                Pseudomyxoma PeritoneiBiological Features Are the Dominant Prognostic Determinants After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
                                                                                                                                                                                Source: Annals of Surgery, Dr Marcello Deraco, Dr Baratti, 2009


                                                                                                                                                                                Articles by Dr David L Bartlett, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                                Source: Journal of Clinical Oncology 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Anuals of Surgical Oncology, 2008

                                                                                                                                                                                HIPEC: The Complexity of Clinical Trials
                                                                                                                                                                                Source: Dr David L Bartlett, UPMC, Society of Surgical Oncology 2008

                                                                                                                                                                                Dr David L Bartlett, Dr James Pingpank, Dr Steven Ahrendt
                                                                                                                                                                                Source: Koch Cancer Treatment Center, UPMC

                                                                                                                                                                                Profile for Dr David L Bartlett
                                                                                                                                                                                Source: UPMC

                                                                                                                                                                                Dr David L Bartlett:
                                                                                                                                                                                Koch Cancer Center
                                                                                                                                                                                Source: UPMC

                                                                                                                                                                                Dr David L Bartlett: Treatment of Liver Cancer
                                                                                                                                                                                Source: UPMC Koch Cancer Center

                                                                                                                                                                                Articles by Dr Jean Bereder, France
                                                                                                                                                                                Study of 300+ Patients Treated with CRS and PIC
                                                                                                                                                                                Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                                Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                                Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                                Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                                Source: Journal of Clinical Oncology,2010

                                                                                                                                                                                Articles by Dr Wim Ceelen, Belgium

                                                                                                                                                                                Dr Wim P Ceelen treats Pseudomyxoma Peritonei with HIPEC www.surgery.ugent.be

                                                                                                                                                                                Articles by Dr Marcello Deraco, Italy

                                                                                                                                                                                Pseudomyxoma PeritoneiBiological Features Are the Dominant Prognostic Determinants After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
                                                                                                                                                                                Source: Annals of Surgery, Dr Marcello Deraco, Dr Baratti, 2009


                                                                                                                                                                                HIPEC Treatment: Dott. Marcello Deraco: Pseudomyxoma Peritonei and Appendix Cancer
                                                                                                                                                                                Source: Dott. Marcello Deraco

                                                                                                                                                                                Articles by Dr D Elias, France

                                                                                                                                                                                Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                                Source: Journal of Clinical Oncology,2010

                                                                                                                                                                                Articles by Dr Jesus Esquivel, USA

                                                                                                                                                                                Learning Curve for CRS and HIPEC
                                                                                                                                                                                Source: Journal of Surgical Oncology, August 2009


                                                                                                                                                                                Laparoscopic CRS and HIPEC Treatment for Peritoneal Mesothelioma
                                                                                                                                                                                Source: Dr Jesus Esquivel, 2009

                                                                                                                                                                                HIPEC Treatment available at St Agnes Hospital
                                                                                                                                                                                Source: Dr Jesus Esquivel

                                                                                                                                                                                Pros and Cons of HIPEC: Dr Jesus Esquivel
                                                                                                                                                                                Source: Oncology Times, Jan 2007

                                                                                                                                                                                Physician Profile for Dr Jesus Esquivel
                                                                                                                                                                                Source: St Agnes Hospital

                                                                                                                                                                                Dr Jesus Esquivel:
                                                                                                                                                                                St Agnes Hospital
                                                                                                                                                                                Source: St Agnes Hospital

                                                                                                                                                                                Articles by Dr Jan Franko, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                                Source: Journal of Clinical Oncology 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                                Click here to read Dr Jan Franko's profile
                                                                                                                                                                                Source: Mercy Medical Center

                                                                                                                                                                                Articles by Dr Gilly, France
                                                                                                                                                                                Study of 300+ Patients Treated with CRS and PIC :
                                                                                                                                                                                Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                                 
                                                                                                                                                                                Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                                Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                                Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                                Source: Journal of Clinical Oncology,2010

                                                                                                                                                                                Articles by Dr Matthew Holtzman, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients Source: Journal of Clinical Oncology 2008

                                                                                                                                                                                Articles by Dr Joachim Jahne, Germany

                                                                                                                                                                                CRS:Stategies to Reduce Post Op Morbidity and Complications
                                                                                                                                                                                Source: Dr Joachim Jahne, April 2009


                                                                                                                                                                                Articles by Dr Santiago Gonzalez-Moreno, Spain

                                                                                                                                                                                Patient Selection for CRS and HIPEC
                                                                                                                                                                                Source: Journal of Surgical Oncology 2009

                                                                                                                                                                                Articles by Dr Martin Goodman, USA

                                                                                                                                                                                Dr Martin Goodman at Tufts University provides HIPEC
                                                                                                                                                                                Source: Tufts University, Boston

                                                                                                                                                                                Articles by Dr Matthew Holtzman, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                                Articles by Dr Laura Lambert, USA

                                                                                                                                                                                CRS and Perioperative Intraperitoneal Chemotherapy for Colorectal Carcinomatosis:
                                                                                                                                                                                Source: Annals of Surgical Oncology. 2007, Lambert, Laura A. and Paul F. Mansfield. 
                                                                                                                                                                                See:
                                                                                                                                                                                http://www.annalssurgicaloncology.org/cgi/content/full/14/11/3037


                                                                                                                                                                                Articles by Dr Edward Levine, USA

                                                                                                                                                                                CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms
                                                                                                                                                                                Source: Dr Edward Levine, ASCO 2008

                                                                                                                                                                                “Appendiceal Carcinoma with Peritoneal Dissemination: Outcomes for the Best of the Best.” 
                                                                                                                                                                                Source: Annals of Surgical
                                                                                                                                                                                Oncology,2007, Dr Edward Levine, WFU

                                                                                                                                                                                Survival Study for Pseudomyxoma Peritonei: DPAM, PMCA, PMCA 1
                                                                                                                                                                                Source: Dr Edward Levine, American Journal of Surgical Pathology, May 2006

                                                                                                                                                                                DPAM and HIPEC Treatment
                                                                                                                                                                                Source: Wake Forest University


                                                                                                                                                                                Articles by Dr Brian W Loggie, USA

                                                                                                                                                                                CRS with HIPEC have improved quality and quantity of life for patients
                                                                                                                                                                                Source:Dr Brian Loggie, 2007

                                                                                                                                                                                Cox II expression in patients with Pseudomyxoma Peritonei and Disseminated Peritoneal Adenomucinosis
                                                                                                                                                                                Source: Dr Brian Loggie

                                                                                                                                                                                Articles referring to Dr Brian Loggie's patients
                                                                                                                                                                                Source: PMP Pals' Network


                                                                                                                                                                                Articles by Dr Andrew Lowy, USA

                                                                                                                                                                                Minimally Invasive Laparoscopic Treatment of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: UCSD, Dr Andrew Lowy, 2009


                                                                                                                                                                                Dr Andrew Lowy:Moores Cancer Center
                                                                                                                                                                                Source: UCSD

                                                                                                                                                                                Treatment of Pancreatic Cancer
                                                                                                                                                                                Source: Dr Andrew Lowy UCSD

                                                                                                                                                                                Articles by Dr Paul Mansfield, USA

                                                                                                                                                                                Profile for Dr Paul Mansfield
                                                                                                                                                                                Source: MD Anderson

                                                                                                                                                                                CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms

                                                                                                                                                                                Source: Dr Paul Mansfield, ASCO 2008

                                                                                                                                                                                CRS and Perioperative Intraperitoneal Chemotherapy for Colorectal Carcinomatosis:
                                                                                                                                                                                Source:
                                                                                                                                                                                Annals of Surgical Oncology. 2007, Lambert, Laura A. and Paul F. Mansfield. 
                                                                                                                                                                                See:
                                                                                                                                                                                http://www.annalssurgicaloncology.org/cgi/content/full/14/11/3037

                                                                                                                                                                                Laparoscopic Staging for Gastric Cancer
                                                                                                                                                                                Source: Dr Paul Mansfield, MDACC, Annals of Surgical Oncology, 2001


                                                                                                                                                                                Laparoscopy for Surgical Oncology
                                                                                                                                                                                Source: MDACC


                                                                                                                                                                                Articles by Dr Brendan J Moran, United Kingdom

                                                                                                                                                                                CRS and HIPEC for the Treatment of Patients age 30-77 years
                                                                                                                                                                                Source: North Hampshire Hospital, Basingstoke UK, 2007

                                                                                                                                                                                Articles by Prof David L Morris, Australia 
                                                                                                                                                                                Radiofrequency Ablation for Treatment of Unresectable Colorectal Pulmonary Metastes

                                                                                                                                                                                Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Radiofrequency ablation for colorectal pulmonary metastases represents a step forward towards a nonsurgical option of combining systemic and local treatment for metastatic disease and is a safe treatment with a low risk profile.
                                                                                                                                                                                Source: David L. Morris, MD, PhD 2009

                                                                                                                                                                                Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan

                                                                                                                                                                                DPAM: Peritonectomy Improves Survival

                                                                                                                                                                                Source Prof David L Morris, 2009

                                                                                                                                                                                Assessment of risk factors following CRS and chemotherapy
                                                                                                                                                                                Source: Dr David L Morris, Dr Tristan Yan, 2009
                                                                                                                                                                                Cost effectiveness of treatment with CRS and HIPEC
                                                                                                                                                                                Source: Dr David L Morris, Dr Tristan Yan, Dec 2009

                                                                                                                                                                                Pseudomyxoma Peritonei Long Term Survival (10 year study) 
                                                                                                                                                                                Source: Annals of Surgical Oncology, 2009, Prof David L Morris, St George Hospital,Univ of New South Wales, Sydney, NSW, AU

                                                                                                                                                                                Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience. 

                                                                                                                                                                                This report demonstrates long-term survival outcomes, acceptable perioperative outcomes, and a learning curve associated with the treatment of patients with pseudomyxoma peritonei.

                                                                                                                                                                                In vivo model for Pseudomyxoma Peritonei research
                                                                                                                                                                                Source: Prof David L Morris, Sydney Australia, 2009

                                                                                                                                                                                Articles by Dr Stefaan Mulier, Belgium

                                                                                                                                                                                Dr Stefaan Mulier provides HIPEC treatment for Pseudomyxoma Peritonei and Peritoneal Carcinomatosis 
                                                                                                                                                                                Source: Leopold Park Clinic in Brussels


                                                                                                                                                                                Articles by Dr Herwart Mueller, German

                                                                                                                                                                                CRS for Senior Patients
                                                                                                                                                                                Source: Dr Herwart Mueller, Germany

                                                                                                                                                                                Articles by Dr Garrett M Nash USA

                                                                                                                                                                                Laparoscopic Surgery for the Treatment of Peritoneal Surface Malignancies including Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Memorial Sloan Kettering, NY

                                                                                                                                                                                Articles by Dr Haydee Ojeda-Fournier, USA   

                                                                                                                                                                                Diagnostic Imaging of Pancreatic Cancer
                                                                                                                                                                                Source: Dr Haydee Ojeda-Fournier, UCSD

                                                                                                                                                                                Articles by Dr Gloria Ortega-Perez, Spain

                                                                                                                                                                                Patient Selection for CRS and HIPEC
                                                                                                                                                                                Source: Journal of Surgical Oncology 2009


                                                                                                                                                                                Articles by Dr James Pingpank, USA

                                                                                                                                                                                Peritoneal Carcinomatois Clinical Trials Study
                                                                                                                                                                                Source: NIH, Dr James Pingpank, Feb 2009


                                                                                                                                                                                Articles by Prof Pompiliu Piso, Germany

                                                                                                                                                                                Peritoneal Carcinomatosis Treatment (Study) with Tumor Honing Peptides
                                                                                                                                                                                Source: Dept of Radiology, Germany 2009

                                                                                                                                                                                Peritoneal Carcinomatosis Prognosis following treatment with surgery and HIPEC
                                                                                                                                                                                Source: Prof P Piso, 2009

                                                                                                                                                                                CRS and HIPEC for the Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Prof Pompiliu Piso, 3rd Annual Symposium, 2008

                                                                                                                                                                                HIPEC Study with laboratory rats
                                                                                                                                                                                Source: Deutscher Krebskongress, 2004

                                                                                                                                                                                Articles by Dr B Ronnett, USA

                                                                                                                                                                                CRS and HIPEC for the Treatment of Peritoneal Dissemination of Appendiceal and Colorectal Neoplasms
                                                                                                                                                                                Source: Dr Edward Levine, ASCO 2008

                                                                                                                                                                                DPAM Long Term Survival
                                                                                                                                                                                Source: Dr BM Ronnett, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                                Articles by Dr Armando Sardi, USA

                                                                                                                                                                                CRS and HIPEC offer longterm survival for Peritoneal Carcinomatosis of disseminated Appendiceal tumor origin
                                                                                                                                                                                Source: Dr Armando Sardi, Mercy Med Center, Journal of American College of Surgeons, Sept 2009

                                                                                                                                                                                Published abstracts by Dr Armando Sardi
                                                                                                                                                                                Source: Mercy Medical Center


                                                                                                                                                                                Steps to Prepare for SurgerySource: Mercy Medical Center

                                                                                                                                                                                Curriculum Vitae for Dr Armando Sardi
                                                                                                                                                                                Source: Mercy Medical Center

                                                                                                                                                                                Profile for Dr Armando Sardi
                                                                                                                                                                                Source: Mercy Medical Center


                                                                                                                                                                                Articles by Dr Perry Shen, USA

                                                                                                                                                                                Dr Perry Shen at WFU provides HIPEC
                                                                                                                                                                                Source: Wake Forest University

                                                                                                                                                                                Articles by Dr Paul H Sugarbaker, USA

                                                                                                                                                                                Mesenteric Cyst resulting in Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, 2010

                                                                                                                                                                                Tailgut Cyst: An Unusual Case of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Tumori, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                                Epithelial appendiceal neoplasms (abstract with availability to purchase article in full)
                                                                                                                                                                                Source: The Cancer Journal, 2009

                                                                                                                                                                                Epithelial appendiceal neoplasms: report reviews 900 cases treated at the Washington Hospital Center
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Cancer Journal, May 2009

                                                                                                                                                                                DPAM Long Term Survival
                                                                                                                                                                                Source: Dr BM Ronnett, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                                Management of mucinous urachal neoplasm presenting as Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, 2008

                                                                                                                                                                                Failure Analysis of Recurrent Disease Following CRS and IPC for Colorectal Cancer with Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Dr Tristan Yan, 2007

                                                                                                                                                                                Treatment of Peritoneal Surface Malignancy
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Dr Tristan Yan, Journal of Transistional Medicine, 2006

                                                                                                                                                                                Cytoreductive Surgery (includes graphic illustrations) Source: Dr Paul H Sugarbaker

                                                                                                                                                                                Indications for use of CRS and HIPEC
                                                                                                                                                                                Source: Dr Paul H Sugarbaker

                                                                                                                                                                                Appendix Cancer Prognosis
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Washington Hospital Center

                                                                                                                                                                                Prognostic indicators for Peritoneal Carcinomatosis originating with gastrointestinal adenocarcinoma
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, 2005

                                                                                                                                                                                Atlas of Appendix Cancer(includes graphic illustrations)
                                                                                                                                                                                Source: Dr Paul H  Sugarbaker


                                                                                                                                                                                Articles referring to Dr Paul Sugarbaker and his patients
                                                                                                                                                                                Source: PMP Pals' Network

                                                                                                                                                                                Articles by Dr V J Verwaal,Holland

                                                                                                                                                                                Population Based Study of Appendiceal Neoplasms and Pseudomyxoma Peritonei
                                                                                                                                                                                Source: ESJO, 2008


                                                                                                                                                                                Cytoreduction and HIPEC Treatment for Appendix Cancer and Pseudomyxoma Peritonei (pdf)
                                                                                                                                                                                Source: Netherlands Cancer Institute, Prof VJ Verwaal, 2006

                                                                                                                                                                                Articles by Dr Tristan Yan, Australia

                                                                                                                                                                                Cost effectiveness of treatment with CRS and HIPEC
                                                                                                                                                                                Source: Dr David L Morris, Dr Tristan Yan, Dec 2009

                                                                                                                                                                                Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan

                                                                                                                                                                                Assessment of risk factors following CRS and chemotherapy
                                                                                                                                                                                Source: Dr David L Morris, Dr Tristan Yan, 2009
                                                                                                                                                                                Failure Analysis of Recurrent Disease Following CRS and IPC for Colorectal Cancer with Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Dr Tristan Yan, 2007

                                                                                                                                                                                Treatment of Peritoneal Surface Malignancy
                                                                                                                                                                                Source: Dr Paul H Sugarbaker, Dr Tristan Yan, Journal of Transistional Medicine, 2006

                                                                                                                                                                                Articles by Dr H Zeh, USA

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis in Colorectal Cancer Patient with Liver Metastasis: Study of 57 Patients
                                                                                                                                                                                Source: Journal of Clinical Oncology 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgical Oncology, 2008

                                                                                                                                                                                CRS and HIPEC for Treatment of Colorectal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgial Oncology, Nov 2008

                                                                                                                                                                                Articles by Dr F Zoetmulder, Holland

                                                                                                                                                                                Population Based Study of Appendiceal Neoplasms and Pseudomyxoma Peritonei
                                                                                                                                                                                Source: ESJO, 2008


                                                                                                                                                                                Cytoreductive Surgery in conjunction with HIPEC

                                                                                                                                                                                Picture

                                                                                                                                                                                CRS (Cytoreductive Surgery) in conjunction with HIPEC:
                                                                                                                                                                                Articles
                                                                                                                                                                                 and Abstracts


                                                                                                                                                                                Study of 300+ Patients Treated with CRS and PIC
                                                                                                                                                                                Abstract of a study of 300+ Pseudomyxoma Peritonei patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Describes "gold standard " of treatment.
                                                                                                                                                                                Source: Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; the Association Française de Chirurgie.
                                                                                                                                                                                Department of Oncologic Surgery, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif Cédex, France March 2010

                                                                                                                                                                                Radiofrequency Ablation for Treatment of Unresectable Colorectal Pulmonary Metastes


                                                                                                                                                                                Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Radiofrequency ablation for colorectal pulmonary metastases represents a step forward towards a nonsurgical option of combining systemic and local treatment for metastatic disease and is a safe treatment with a low risk profile.

                                                                                                                                                                                Terence C. Chua, BScMed (Hons), MBBS 1, Kelly Thornbury, BMed 1, Akshat Saxena, BMedSc 1, Winston Liauw, MBBS, M Med Sci 2, Derek Glenn, MBBS 3, Jing Zhao, MD 1, David L. Morris, MD, PhD 1 *
                                                                                                                                                                                1Department of Surgery, University of New South Wales, St George Hospital, Sydney, Australia
                                                                                                                                                                                2Cancer Care Center, St George Hospital, Sydney, Australia
                                                                                                                                                                                3Department of Radiology, St George Hospital, Sydney, Australia
                                                                                                                                                                                Source: AMC Feb 2010 

                                                                                                                                                                                Treatment of Peritoneal Malignancies, including Pseudomyxoma Peritonei with CRS and HIPEC

                                                                                                                                                                                CONCLUSION: It is important to recognize the role of and indications for CRS and HIPEC. Biologic factors of the disease and completeness of resection are important prognostic factors. Cytoreductive surgery, combined with intraperitoneal chemotherapy, can improve survival in selected patients with peritoneal-based malignancies.

                                                                                                                                                                                Source:Department of Surgical Oncology, National Cancer Centre of Singapore, Singapore 2010

                                                                                                                                                                                Study of 523 Colorectal Peritoneal Carcinomatosis Cases: CRS and IPC
                                                                                                                                                                                Source: Journal of Clinical Oncology,2010

                                                                                                                                                                                12 Year Study of CRS and HIPEC for Pseudomyxoma Peritonei Treatment
                                                                                                                                                                                Source: In Vivo, 2009


                                                                                                                                                                                Morbidity and Mortality: Study of HIPEC and CRS for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annals of Surgery, Feb 2009, Dr David Morris, Dr Tristan Yan



                                                                                                                                                                                CRS with HIPEC have improved quality and quantity of life for patients
                                                                                                                                                                                Source:Dr Brian Loggie, 2007

                                                                                                                                                                                HIPEC: Complexity
                                                                                                                                                                                Source: Dr David L Bartlett,Journal of Surgical Oncology

                                                                                                                                                                                Twelve year study of Pseudomyxoma Peritonei Treatment with CRS and HIPEC
                                                                                                                                                                                Source: San Giuseppe Hospital, June 2009

                                                                                                                                                                                Pleural Pseudomyxoma Peritonei Treatment with Thoracic CRS and HIPEC
                                                                                                                                                                                Source: University of New South Wales, Australia, 2009

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with CRS and HIPEC
                                                                                                                                                                                Source: Universite de Montreal, Canada, 2009

                                                                                                                                                                                HIPEC Treatment provided at St Agnes
                                                                                                                                                                                Source: Dr Jesus Esquivel

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with Cytoreductive Surgery and HIPEC
                                                                                                                                                                                Source: British Journal of Surgery, Aug 2008

                                                                                                                                                                                Tailgut Cyst: An Unusual Case of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Tumori, Dr Paul H Sugarbaker, 2009

                                                                                                                                                                                Pseudomyxoma Peritonei Treatment with Chemo Hyperthermic Perfusion(CHPP)
                                                                                                                                                                                Source: Pub Med 2009

                                                                                                                                                                                CRS and HIPEC for Treatment of Peritoneal Carcinomatosis
                                                                                                                                                                                Source: Annuals of Surgical Oncology, 2008
                                                                                                                                                                                International Consensus of PSMG for CRS and HIPEC
                                                                                                                                                                                Source: Springerlink, Oct 2006


                                                                                                                                                                                Laparoscopy; Minimally Invasive Staging and Surgery

                                                                                                                                                                                Picture

                                                                                                                                                                                Laparoscopy surgery
                                                                                                                                                                                includes the use of a thin, narrow, tube shaped instrument inserted into the abdominal wall. Laparoscopy may be used as a diagnostic tool, and has become a surgical option for specific patients, providing a less invasive (and less expensive) alternative to more extensive surgery. Recuperation from laparoscopy requires less hospitalization due to a faster recovery period, with less trauma and post op pain.

                                                                                                                                                                                The following articles and abstracts pertaining to mesothelioma, pseudomyxoma peritonei, gastric, liver, ovarian and pancreatic cancer are posted for your reference.
                                                                                                                                                                                 
                                                                                                                                                                                 
                                                                                                                                                                                Laparoscopy for Oncological Surgery (this article provides a detailed explanation for patients)
                                                                                                                                                                                Source: MDAnderson, Houston TX

                                                                                                                                                                                Laparoscopic Mucin Removal of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Dept of OB GYN, Kinko Univ, Osaka Japan, 2009

                                                                                                                                                                                Minimally Invasive Laparoscopic Surgery
                                                                                                                                                                                Source: Mercy Medical Center

                                                                                                                                                                                Minimally Invasive Laparoscopic Surgery, Liver, Pancreas
                                                                                                                                                                                Source: UCSD, Dr Andrew Lowy, 2009

                                                                                                                                                                                Laparoscopic CRS and HIPEC Treatment for Peritoneal Mesothelioma
                                                                                                                                                                                Source: Dr Jesus Esquivel, 2009

                                                                                                                                                                                Laparoscopic Surgery for the Treatment of Peritoneal Surface Malignancies including Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Memorial Sloan Kettering, NY

                                                                                                                                                                                Laparoscopic Surgery for the Treatment of Liver Cancer, Pancreas Cancer
                                                                                                                                                                                Source: University of Southern California


                                                                                                                                                                                Laparoscopic Staging for Gastric Cancer
                                                                                                                                                                                Source: Dr Paul Mansfield, MDACC, Annals of Surgical Oncology, 2001


                                                                                                                                                                                Laparoscopic Colon Resection
                                                                                                                                                                                Source: UPMC Koch Cancer Treatment Center


                                                                                                                                                                                Laparoscopic Surgery for Liver Cancer
                                                                                                                                                                                Source: Dr David L Bartlett UPMC Koch Cancer Center

                                                                                                                                                                                Laparoscopic Surgery for Whipple Procedure, Pancreatic
                                                                                                                                                                                Source: USC Norris Cancer Center


                                                                                                                                                                                Laparoscopic Surgery, Gastric and Esophageal Cancers
                                                                                                                                                                                Source: Dr Charles Filipi, Creighton University


                                                                                                                                                                                Laparoscopic restoration of the colon continuity after Hartmann procedure
                                                                                                                                                                                Source: Pub Med 2009

                                                                                                                                                                                Laparoscopic Management of Ovarian Cyst
                                                                                                                                                                                Source: Springerlink:2008

                                                                                                                                                                                Laparoscopic Management of Pseudomyxoma Peritonei
                                                                                                                                                                                Source: Cleveland Clinic 1999

                                                                                                                                                                                Cecum Preserving Right Hemicolectomy
                                                                                                                                                                                Source: Clinical Robotics, 2010

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